AP1189 acetate

SKU: orb1297993

Description

AP1189 acetate is a selective biased agonist for the melanocortin 1 receptor (MC1R) and melanocortin 3 receptor (MC3R). Its functional selectivity makes it a valuable research tool for studying melanocortin receptor signaling in vitro and exploring pathways related to inflammation and energy homeostasis in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 959850-74-9
• MW: 358.35
• Purity: 99.95% (May vary between batches)
• Formula: C₁₆H₁₈N₆O₄
• SMILES: O=[N+](C1=CC=CC=C1N2C(/C=C/C=N/NC(N)=N)=CC=C2)[O-].CC(O)=O
• Target: Melanocortin Receptor
• Solubility: DMSO:50 mg/mL (139.53 mM)

Bioactivity

• In Vivo:
  Oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ～3-fold.
• In Vitro:
  Added to macrophage cultures, AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AP 1189 Acetate, AP1189 acetate, AP1189 Acetate, AP-1189 acetate, AP-1189 Acetate, melanocortin 3 (MC3), Melanocortin Receptor, melanocortin-1 receptor, MelanocortinReceptor

Compound Identifiers

PubChem CID

163358504