AOH1160

SKU: orb1309993

Description

AOH1160 is a small molecule PCNA inhibitor that disrupts DNA replication, leading to cell cycle arrest and apoptosis. It is utilized in cancer research to study replication stress and has shown efficacy in both cellular and animal models of various malignancies.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 2089314-57-6
• MW: 396.44
• Purity: 99.16% (May vary between batches)
• Formula: C₂₅H₂₀N₂O₃
• SMILES: C(NCC(NC1=C(OC2=CC=CC=C2)C=CC=C1)=O)(=O)C=3C4=C(C=CC3)C=CC=C4
• Target: Apoptosis|||DNA/RNA Synthesis
• Solubility: DMSO:45 mg/mL (113.51 mM)

Bioactivity

• Target IC50:
  PCNA:
• In Vitro:
  AOH1160 selectively kills many types of cancer cells with mean GI50 of 330 nM and does not cause toxicity to nonmalignant cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA Synthesis, DNA replication, Apoptosis, AOH 1160, AOH1160, AOH-1160, PCNA, N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

126718383