Anwuligan

SKU: orb1222886

Description

Macelignan is a lignan which can be found in the nutmeg. Macelignan acts as an NSAID with antioxidant, free radical scavenging, and neuroprotective activities.

Key Properties

• CAS Number: 107534-93-0
• MW: 328.41
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₄O₄
• SMILES: c1(c(cc(cc1)C[C@@H]([C@@H](Cc1cc2OCOc2cc1)C)C)OC)O
• Target: Estrogen Receptor/ERR
• Solubility: DMSO : ≥ 30 mg/mL; 91.35 mM

Bioactivity

• In Vivo:
  Macelignan (oral administration; 15 mg/kg; every day for three weeks) exhibits In vivo anti-diabetic effects. The baseline (day 0) fasting blood glucose levels does not differ between groups; at the end of the experiment, the values of the Macelignan-treated group are significantly lower compared to the diabetic control group in C57BL/KsJ-db/db mice. Animal model: Male C57BL/KsJ-db/db mice. Dosage: 15 mg/kg. Administration: Oral administration; 15 mg/kg; every day for three weeks. Result: Significantly reduced the blood glucose levels in mice.
• In Vitro:
  Macelignan (1-50 μM; 72 hours) does not reduce cell viability alone, however, UVB treatment, even at the lowest dose of 30 mJ/cm2, reduces HaCaT cell viability in a dose-dependent mannner, it reduces approximately 80% of control values at 100 μM in hacat cells. Macelignan (0.1-1 μM; 24 hours) decreases COX-2 expression in a concentration-dependent manner, and at the highest concentration of macelignan (1 μM), COX-2 expression is inhibited by almost 50% in hacat cells. TCell Viability Assay Cell line: Hacat cells. Concentration: 1 μM; 2.5 μM; 5 μM; 10 μM; 15 μM; 50 μM Incubation time: 72 hours. Result: Induced cell death by UVB irradiation at 30 mJ/cm2 from 10 μM. Western blot analysis. Cell line: Hacat cells. Concentration: 0.1 μM; 0.5 μM; 1 μM Incubation time: 24 hours. Result: Reduced UVB-induced COX-2 expression in cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Macelignan

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR