Antiviral agent 34

SKU: orb2279132

Description

Antiviral agent 34 is a potent, orally bioavailable inhibitor of influenza A and B virus RNA polymerase. It is utilized in research to study viral replication mechanisms and has demonstrated antiviral activity in both cellular and animal models of influenza infection.

Research Area

Cell Biology, Immunology & Inflammation, Molecular Biology

Key Properties

• CAS Number: 945152-88-5
• MW: 487.66
• Purity: 99.51% (May vary between batches)
• Formula: C₂₉H₃₃N₃O₂S
• SMILES: O=C(NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C3=CC=C(C=C3)C(C)(C)C
• Target: Antiviral|||DNA/RNA Synthesis
• Solubility: DMSO:100 mg/mL (205.06 mM)

Bioactivity

• Target IC50:
  influenza B:0.8 nM (EC50)|influenza A (EC50):0.8 nM
• In Vivo:
  In BALB/c mice, Antiviral agent 34 (1 g/kg/d, administered orally for 14 days) was well tolerated at a dose of 1 g/kg with low acute toxicity. It provided approximately 50% protection in mice infected with a lethal dose of H1N1.
  Read more...
• In Vitro:
  In MDCK cells, Antiviral agent 34 (0-470 nM; 24 hours) exhibited low toxicity to MDCK cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RNASynthesis, RNA Synthesis, RNA polymerase I, Antiviral, Antiviralagent34, DNA Synthesis, DNASynthesis

Compound Identifiers

PubChem CID

17235233