Antitumor agent-174

SKU: orb3134812

Description

Antitumor agent-174 (Compound 10) directly binds to the N-terminal site of Hsp90, promoting the degradation of β-catenin and thereby inhibiting Wnt/β-catenin signaling. This compound effectively suppresses the proliferation of colorectal cancer (CRC) cells, induces S and G2/M phase arrest, and prevents cell colony formation. It downregulates proteins such as CDK1, Cyclin D1, c-Myc, Cyclin B1, and Cyclin A2, while upregulating P21. Antitumor agent-174 exhibits significant antitumor activity against CRC, offering excellent pharmacokinetics and low toxicity.

Research Area

Cell Biology, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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Formula	C₂₀H₁₈Cl₂N₂
Target	Wnt/beta-catenin,HSP,c-Myc,CDK

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

Wnt/beta-catenin,HSP,c-Myc,CDK

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