Antitumor agent-171

SKU: orb2646165

Description

Antitumor agent-171 is a potent small molecule inhibitor of the β-catenin/BCL9 interaction (IC50=1.61 µM) with high affinity for β-catenin (Kd=0.63 µM). It suppresses Wnt/β-catenin signaling downstream gene expression (Axin2 IC50=0.84 µM), inhibits cancer cell viability, and demonstrates in vivo antitumor activity alongside immunomodulatory effects such as T-cell activation.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3003004-76-7
• MW: 643.78
• Formula: C₃₅H₄₅N₇O₅
• SMILES: N(CC1=CC=C(C=C1)C=2C=NNC2)(C(N[C@@H]3CN(CCC3)C4=CC(OC(C(NCC(=O)N5CC[C@H](O)C5)=O)(C)C)=CC=C4)=O)C6CC6
• Target: Wnt/beta-catenin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171904677