Antiproliferative agent-34

SKU: orb1944275

Description

Antiproliferative Agent-34 (Compound A14) is a multitarget kinase inhibitor with potent activity against mutant EGFR (L858R/T790M, IC50 177 nM) and several other kinases including JAK2 and FLT3. It demonstrates strong antiproliferative effects in NSCLC cell lines like H1975, with potency significantly enhanced under hypoxic conditions. This profile supports its research application in studying oncogenic signaling and hypoxia-driven resistance in cancer models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2910858-34-1
• MW: 529.55
• Formula: C₂₇H₂₇N₇O₅
• SMILES: O=[N+](C1=NC=CN1CCOCCOC(C=C2NC3=NC=CC(C(C4=CC=CC=C45)=CN5C)=N3)=C(C=C2)OC)[O-]
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168510571