Antide

SKU: orb3054015

Description

Antide (D-21074) is a potent LHRH antagonist. Antide also can be used for the research of prostatic cancer.

Key Properties

• CAS Number: 112568-12-4
• MW: 1591.29
• Purity: >98% (HPLC)
• Formula: C₈₂H₁₀₈ClN₁₇O₁₄
• Solubility: H2O : 10 mg/mL (6.28 mM; ultraphonic)

Bioactivity

• In Vivo:
  Animal model: Cynomolgus monkey and rat. Dosage: 1, 3, 6, 10 and 15 mg/kg. Administration: Subcutaneous, once or on 5 consecutive days. Result: Had a dose-dependent inhibitory effect on serum concentration of LH (only rat) and testosterone and on the weights of the testes, prostates and seminal vesicles. Achieved long-lasting castration-like effects at concentrations between 6 (less than or equal to 8 weeks) and 15 mg/kg (greater than 8 weeks) in the rat. Induced a prolonged inhibitory effect only at 15 mg/kg and the duration was only 2-3 weeks in the cynomolgus monkey.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only