Anticancer agent 306

SKU: orb3210522

Description

Anticanceragent 306, a spirotetraacid derivative, serves as an inhibitor of MMP1, MMP7, and PLK1. It exhibits antiproliferative effects on H1299, RKO, and MCF-7 cells, with IC50 values of 19.25 μM, 3.29 μM, and 102.36 μM, respectively. The compound induces cell cycle arrest by upregulating p21 protein and downregulating CCND1 and CCNB1 proteins, and it modulates Bcl-2 and Bax expression to trigger apoptosis (apoptosis). Furthermore, by downregulating MMP1 and MMP7 proteins, it inhibits tumor invasion and metastasis. Anticanceragent 306 is applicable in studies related to lung cancer, colorectal cancer, and breast cancer.

Key Properties

• CAS Number: 3043892-01-6
• MW: 382.28
• Formula: C₁₉H₂₁Cl₂NO₃
• SMILES: O=C1NC2(C(OC(=O)CC(C)C)=C1C=3C=CC(Cl)=CC3Cl)CCCC2
• Target: CDK,Bcl-2 Family,PLK,Apoptosis,Caspase,PAK,MMP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK,Bcl-2 Family,PLK,Apoptosis,Caspase,PAK,MMP