Anti-inflammatory agent 79

SKU: orb3134139

Description

Anti-inflammatory agent 79 (compound 17q) is an isoquinolinone derivative-based HIF-1 inhibitor (IC50: 0.55 μM), effectively blocking HIF-1 signaling and promoting the degradation of HIF-1α. It inhibits synovial invasion and migration, as well as angiogenesis. In mouse inflammation models, Anti-inflammatory agent 79 effectively reduces foot swelling and arthritis and lowers levels of inflammatory factors and angiogenesis in vivo.

Research Area

Epigenetics & Chromatin, Metabolism Research

Images & Validation

−

Key Properties

−

Formula	C₂₁H₁₇NO₂
Target	HIF/HIF Prolyl-Hydroxylase

Storage & Handling

−

Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol

HIF/HIF Prolyl-Hydroxylase

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols