Anti-inflammatory agent 49

SKU: orb1941713

Description

Anti-inflammatory agent 49 is a selective inhibitor that disrupts the Drp1-Fis1 protein interaction and suppresses Drp1 GTPase activity. This small molecule serves as a valuable research tool for investigating mitochondrial fission mechanisms in models of neurodegenerative and cardiovascular diseases, both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 851471-44-8
• MW: 466.52
• Purity: 99.97% (May vary between batches)
• Formula: C₂₁H₂₂N₈O₃S
• SMILES: O=C1NC(=O)N(C(N)=C1N(C(=O)CSC=2N=C3N=C(C=C(N3N2)C)C)C)CC=4C=CC=CC4
• Target: Others,GTPase,Dynamin
• Solubility: DMSO:80 mg/mL (171.48 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.07 mM)

Bioactivity

• In Vivo:
  The anti-inflammatory agent 49 (10 mg/kg, every 8 hours for 72 hours) effectively treats endotoxemia induced by LPS in mice .
• In Vitro:
  In H9c2 cells, the anti-inflammatory agent 49 (2 µM; 16 hours) reduced the percentage of cells with fragmented mitochondria. The percentage of fragmented cells decreased from 22% (LPS + Veh) to 9% (LPS + SC9), compared to 4% in the absence of LPS.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GTPase

Compound Identifiers

PubChem CID

2472109