Anti-inflammatory agent 113

SKU: orb3210160

Description

Anti-inflammatory agent 113 (compound B5) is a cathepsin L (CTSL) inhibitor and anti-inflammatory compound with an IC50 for CTSL of 5.52 μM. It hinders the maturation of CTSL, downregulates the activation of NF-κB and p38 MAPK signaling pathways, and binds stably at the CTSL active site through non-covalent interactions with Asp162, Cys25, and Glu63. This compound also inhibits the production of pro-inflammatory cytokines (IL-6, IL-8), reduces pulmonary infiltration of inflammatory cells, and alleviates lung tissue damage. Anti-inflammatory agent 113 is applicable in research on acute lung injury.

Key Properties

• Target: Cysteine Protease

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Cysteine Protease