Ansofaxine hydrochloride

SKU: orb1221010

Description

Ansofaxine (LY03005; LPM570065) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723 763 and 491 nM respectively).(In Vivo):Ansofaxine rapidly penetrates the rat striatum, converts into desvenlafaxine and exhibits larger total exposure compared with the administration of desvenlafaxine. Acute and chronic administration of oral suspension of ansofaxine increases the 5-HT, dopamine and norepinephrine levels more than the relative administration of desvenlafaxine. Unlike desvenlafaxine, acute administration of an intravenous ansofaxine solution does not induce the undesirable 90% decrease in extracellular 5-HT levels. The acute administration of ansofaxine shows a capped increase in extracellular 5-HT levels when combined with WAY-100635. Acute and chronic administration of ansofaxine reduces the immobility time more than the relative administration of desvenlafaxine.

Key Properties

• CAS Number: 916918-84-8
• MW: 417.97
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₂ClNO₃
• SMILES: Cl.CN(C)CC(c1ccc(OC(=O)c2ccc(C)cc2)cc1)C1(O)CCCCC1
• Target: 5-HT Receptor
• Solubility: DMSO: 30 mg/mL (71.77 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY03005 | LPM570065

Quick Database Links

Gene Symbol

5-HT Receptor