(-)-Anonaine

SKU: orb1684762

Description

(-)-Anonaine is a natural product with broad bioactivity, including antimalarial, antibacterial, and anticancer properties. Research demonstrates it induces apoptosis and DNA damage in HeLa and h1299 cancer cells via Bax/caspase pathways, supporting its use in oncology and pharmacology studies.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 1862-41-5
• MW: 265.31
• Purity: 99.66% (May vary between batches)
• Formula: C₁₇H₁₅NO₂
• SMILES: C=12C3=C4C(=CC1CCN[C@@]2(CC=5C3=CC=CC5)[H])OCO4
• Target: Apoptosis,Antioxidant,Antifungal,GST,Parasite
• Solubility: DMSO:2.66 mg/mL (10.03 mM)

Bioactivity

• Target IC50:
  HepG2 cells:38.3 ± 2.3 μg/ml(CC50)|HepG2 cells:23.2 ± 2.7 μg/ml
• In Vitro:
  (-)-Anonaine (50-200 μM ; 24h ; ) exhibited significant inhibition to cell growth and migration activities on human lung cancer H1299 cells. (-)-Anonaine (10-200 μM) significant nuclear damages of H1299 cells were observed treatment in a comet assay, whereas higher concentrations (6 and 30 mM) of (-)-anonaine concentrations were required to cause DNA damages in an in vitro plasmid cleavage assay.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p53, Fungal, Apoptosis, Antioxidant, Anonaine, Caspase, Bcl-2, ()Anonaine, ( ) Anonaine, P. falciparum

Compound Identifiers

PubChem CID

160597