Angiotensinogen (1-14), human

SKU: orb1679494

Description

Angiotensinogen (1-14), human, is the N-terminal fragment of the liver-synthesized precursor protein cleaved by renin to yield angiotensin I. This peptide is a key research tool for studying the renin-angiotensin system in cardiovascular and renal research, applicable in both in vitro enzymatic assays and in vivo physiological studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 104180-23-6
• MW: 1760.01
• Formula: C₈₃H₁₂₂N₂₄O₁₉
• SMILES: C([C@H](CC1=CN=CN1)NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCNC(=N)N)=O)C(C)C)=O)=O)[C@H](CC)C)=O)(=O)N3[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CN=CN5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC6=CN=CN6)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)[C@H](CC)C)=O)[C@H](C)C)=O)CC(C)C)=O)=O)=O)CCC3
• Target: Others,Endogenous Metabolite
• Solubility: H2O:≥ 4.8 mg/mL

Bioactivity

• In Vitro:
  Angiotensinogen (1-14), human (AGT), the common precursor of the angiotensin peptide family, consists of 485 amino acids in humans, with the N-terminal 33 amino acids serving as a signal peptide. Renin specifically cleaves amino acids 34-43 (the 10th residue after the signal peptide is removed) to release angiotensin I (AngI), which then generates a variety of bioactive peptides through a cascade reaction. Notably, this enzymatic cleavage mechanism is conserved across species—most mammalian AGTs can be recognized and cleaved by human renin, and synthetic peptides containing only the N-terminal sequence can mimic the function of the natural substrate. This property suggests that the N-terminal domain of AGT plays a crucial role in renin recognition. [1-2]

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Angiotensinogen (1 14), human, Angiotensinogen (114), human, Angiotensinogen , human

Compound Identifiers

PubChem CID

163325299