Angiotensin (1-7)

SKU: orb2693830

Description

Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity.

Research Area

Cardiovascular Research

Key Properties

• Target: Angiotensin Receptor; Angiotensin-converting Enzyme (ACE); Endogenous Metabolite
• CAS Number: 51833-78-4
• MW: 899.03
• Purity: ≥95%
• Formula: C₄₁H₆₂N₁₂O₁₁
• Protein Sequence: DRVYIHP

Storage & Handling

• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Angiotensin Receptor; Angiotensin-converting Enzyme (ACE); Endogenous Metabolite