Angiotensin (1-7) acetate

SKU: orb1692838

Description

Angiotensin (1-7) acetate is a bioactive peptide fragment with antifibrotic and cardioprotective properties, acting as an endogenous ACE inhibitor. It is utilized in research areas including cardiovascular disease, oncology, and virology, with applications in studying atherosclerosis, tumor cell growth, and SARS-CoV-2 infection mechanisms in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2855063-75-9
• MW: 959.06
• Purity: 98.60% (May vary between batches)
• Formula: C₄₃H₆₆N₁₂O₁₃
• SMILES: C(C)(O)=O.C([C@H](CC1=CN=CN1)NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCNC(=N)N)=O)[C@H](C)C)=O)=O)[C@H](CC)C)=O)(=O)N3[C@H](C(O)=O)CCC3
• Target: Endogenous Metabolite,RAAS,Angiotensin-converting Enzyme (ACE)
• Solubility: H2O:50 mg/mL (52.13 mM)

Bioactivity

• Target IC50:
  ACE:0.65 μM
• In Vivo:
  METHODS: Angiotensin (1-7) acetate (0.01-0.06 mg/kg,daily) was used to treat DSS-induced colitis mice, and colonic expression/activity profiles of ACE2, Ang 1-7, MAS1-Receptor (MAS1-R), MAPK family and Akt were determined by western blotting and immunofluorescence. RESULTS: Enhanced colonic expression of ACE2, Ang 1-7, and MAS1-R was observed in mice after Angiotensin (1-7) acetate treatment and significantly ameliorated DSS-induced colitis.
• In Vitro:
  Pretreatment with Angiotensin (1-7) acetate (2 μM) significantly inhibited the degradation of 125I-[Tyr0]-BK as well as the appearance of BK-(1-7) and BK-(1-5) metabolites in the coronary vascular ring; Angiotensin (1-7) acetate inhibited the angiotensin-converting enzyme activity of purified canine angiotensin converting enzyme with an IC50 of 0.65 μM.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ACE, Angiotensin, Angiotensin (1 7) (acetate), Angiotensin (17) (acetate), Ang-(1-7) acetate, TXA127 acetate, Talfirastide acetate

Compound Identifiers

PubChem CID

132976063