Andarine

SKU: orb1941046

Description

Andarine (S-4;GTx007) is a non-steroidal selective androgen receptor modulator (SARM) with Ki of 4 nM, efficaciously stimulated AR-mediated reporter gene expression; demonstrates in vivo androgenic and anabolic activity, stimulates the anabolic organs more than the androgenic organs; improves muscle strength and body composition and prevents bone loss in orchidectomized rats.(In Vivo):GTx-007 (S-4) is only a partial agonist in the prostate and seminal vesicles, restoring them to 33.8 and 28.2% of intact animals, respectively.GTx-007 significantly increased uterine expression of Wnt4 and Wnt7a.

Key Properties

• CAS Number: 401900-40-1
• MW: 441.3579
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈F₃N₃O₆
• SMILES: O=C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)[C@@](C)(O)COC2=CC=C(NC(C)=O)C=C2
• Target: Androgen Receptor (AR)
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  GTx-007 (S-4) is only a partial agonist in the prostate and seminal vesicles, restoring them to 33.8 and 28.2% of intact animals, respectively. GTx-007 significantly increased uterine expression of Wnt4 and Wnt7a. Animal model: Female C57BL/6J mice. Dosage: 0.5 mg/mouse. Administration: Seven daily subcutaneous injections. Result: Resulted in a highly heterogeneous pattern of AR expression in all compartments, with a significant increase of AR-positive cells in the luminal epithelium compared to VC. Had approximately ten glands per uterine cross-section within an endometrium, with a compact stroma, consistent with overall endogenous steroid depletion.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GTx-007 | S-4 | GTx007

Quick Database Links

Gene Symbol

Androgen Receptor (AR)