Ancitabine hydrochloride

SKU: orb1308083

Description

Ancitabine hydrochloride is a prodrug of cytarabine that undergoes slow hydrolysis to release the active antimetabolite. Its conversion provides sustained cytarabine levels, leading to S-phase-specific termination of DNA replication and inhibition of DNA polymerase, which is utilized in oncology research for studying leukemia and solid tumor models both in vitro and in vivo.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 10212-25-6
• MW: 261.66
• Purity: 99.02%
• Formula: C₉H₁₂ClN₃O₄
• SMILES: Cl.[C@@H]12[C@@H](Oc3n1ccc(=N)n3)[C@@H]([C@H](O2)CO)O
• Target: Virus Protease,Autophagy,DNA/RNA Synthesis
• Solubility: H2O:26.31 mg/mL (100.55 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.82 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:10 mg/mL (38.22 mM)

Bioactivity

• In Vivo:
  Cyclocytidine exhibits its most pronounced effects on cells that require DNA replication and are in the rapid division phase of mitosis. It inhibits DNA and RNA polymerases and nucleotide reductase, which are essential for DNA synthesis. Structurally similar to human deoxynucleosides, Cyclocytidine HCl (Ancitabine), integrates into human DNA, resulting in cell death. It serves as a prodrug of Cytarabine.
• In Vitro:
  Cyclocytidine, an effective immunosuppressant, antiviral, and antitumor agent, can be used in the treatment of leukemia. Its maximal inhibitory effect is achieved through administration via various composite injection methods.

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 145668 HCl, Ancitabine, Autophagy, CMV, DNA Synthesis, DNA/RNA Synthesis, DNASynthesis, Cyclo-C, Cyclo-C HCl, Cyclo-CMP, Cyclo-CMP hydrochloride, Cyclocytidine, Cyclocytidine HCl, Cyclocytidine hydrochloride, RNASynthesis, RNA Synthesis

Compound Identifiers

PubChem CID

25050