Anacardic Acid

SKU: orb1300811

Description

Anacardic Acid

Research Area

Epigenetics & Chromatin, Infectious Disease & Virology

Key Properties

• CAS Number: 16611-84-0
• MW: 348.52
• Purity: 97.47%
• Formula: C₂₂H₃₆O₃
• SMILES: CCCCCCCCCCCCCCCc1cccc(O)c1C(O)=O
• Target: Histone Acetyltransferase,Antibacterial,Epigenetic Reader Domain
• Solubility: Ethanol:17.4 mg/mL (49.93 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (9.47 mM);DMSO:252 mg/mL (723.06 mM)

Bioactivity

• Target IC50:
  PCAF(p300/CREB-binding protein-associated factor):5 μM|p300 HAT:8.5 μM
• In Vivo:
  Anacardic acid decreases over-expression of Gata4, α-MHC, and cTnT in fetal mouse hearts exposed to ethanol. Anacardic acid inhibits binding of PCAF, P300 to the promoter of Gata4.
• In Vitro:
  Anacardic acid is an inhibitor of several Clinicalally targeted enzymes such as HATs, NF-kB, LOX-1, xanthine oxidase, tyrosinase, and ureases. Anacardic acid is also an effective inhibitor of Tip60 in vitro. It inhibits the Tip60-dependent acetylation and activation of the ATM protein kinase in HeLa cells and sensitizes the cells to the cytotoxic effects of radiation.
• Cell Research:
  HeLa and 293T cells are grown in Dulbecco's modified Eagle's medium/10% fetal calf serum. SQ20B and SCC35 squamous cell carcinoma cell lines are cultured in modified eagles medium/10% fetal calf serum. For anacardic acid (EMD Biosciences, CA) exposure, cells are preincubated with anacardic acid (0-100 μM) for 40 min, irradiated, then allowed to recover for 4 h. Cells are then switched to fresh media and allowed to grow for 10 days.
• Animal Research:
  Animal Models: 9 to 11 week old Kunming mice. Formulation: Dissolved in DMSO,co-injected with ethanol. Dosages: 0,1.25,2.5,5,10 mg/kg. Administration: i.p.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, PCAF(p300/CBP-associated factor), p300 histone acetylatransferase, p300/CBP, HistoneAcetyltransferase, Histone Acetyltransferase, HATs, HAT, Inhibitor, EpigeneticReaderDomain, Epigenetic Reader Domain, Ginkgolic Acid C15:0, Hydroginkgolic acid, Bacterial, Anacardic Acid, 6-pentadecylsalicylic Acid

Compound Identifiers

PubChem CID

167551