Anabasine

SKU: orb1685509

Description

Anabasine is a tobacco-derived alkaloid that acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). This insecticidal compound is used in neuroscience research, including in vitro studies on depolarization of human cell lines like TE671, to investigate receptor function and neuropharmacology.

Research Area

Neuroscience

Key Properties

• CAS Number: 494-52-0
• MW: 162.23
• Purity: 99.27%
• Formula: C₁₀H₁₄N₂
• SMILES: C1CC[C@H](NC1)c1cccnc1
• Target: AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (12.33 mM);DMSO:50 mg/mL (308.2 mM)

Bioactivity

• In Vivo:
  Anabasine significantly reverses impairment at doses of 0.2 mg/kg (p<0.05) and 2 mg/kg (p<0.025), without any significant effects on response latency when administered alone. However, the 0.06 mg/kg Anabasine dose exacerbates dizocilpine-induced impairment, increasing non-response trials significantly (p<0.05), and none of the Anabasine doses affect choice accuracy on their own .

Storage & Handling

• Storage: keep away from direct sunlight | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(-)-Anabasine, (S)-Anabasine, Anabasine, Nicotinic Receptor, nAChR

Compound Identifiers

PubChem CID

205586