β-Amyloid (1-15)

SKU: orb1679790

Description

β-Amyloid (1-15) is a proteolytic fragment of the amyloid-β precursor protein, widely utilized in Alzheimer's disease research. This peptide is employed in both in vitro and in vivo studies to investigate early-stage aggregation mechanisms and immunological responses.

Research Area

Neuroscience

Key Properties

• CAS Number: 183745-81-5
• MW: 1826.84
• Purity: 99.88%
• Formula: C₇₈H₁₀₇N₂₅O₂₇
• SMILES: [C@H](CC1=CN=CN1)(C(N[C@@H](CC2=CN=CN2)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC(CNC([C@@H](NC([C@@H](NC([C@H](CC4=CN=CN4)NC([C@@H](NC([C@H](CC5=CC=CC=C5)NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)C)=O)CCC(O)=O)=O)=O)CCCNC(=N)N)=O)=O)CC(O)=O)=O)CO)=O)=O)=O)CCC(O)=O)=O)[C@H](C)C)=O
• Target: Beta Amyloid
• Solubility: H2O:30 mg/mL (16.42 mM)

Bioactivity

• In Vitro:
  Produced by concerted β- and α-secretase cleavage of amyloid-β protein precursor (AβPP), β-Amyloid (1-15) appears to be a sensitive acute pharmacodynamic biomarker for γ-secretase inhibition. It may have several advantages compared to measuring longer cerebrospinal fluid (CSF) Aβ species.

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta Amyloid, beta-Amyloid 1-15, BetaAmyloid, beta-Amyloid, b-Amyloid, bAmyloid, b-Amyloid 1-15, b Amyloid, Amyloid beta-Protein, Amyloid b-Protein, Amyloid β-Protein, Amyloid β-Protein (1-15), amyloid-β, β Amyloid, β Amyloid (1 15), βAmyloid (115), β-Amyloid, β-Amyloid 1-15, βAmyloid

Compound Identifiers

PubChem CID

131675933