Amygdalin

SKU: orb1305010

Description

Amygdalin (Laetrile) is a research compound with demonstrated anti-inflammatory, antifibrotic, and antitumor properties. In vitro studies show it induces apoptosis in prostate cancer cells via caspase-3 and modulates Bcl-2/Bax. Research also indicates synergistic chondroprotective effects with HSYA against IL-1β-induced disc degeneration in rat models.

Key Properties

• CAS Number: 29883-15-6
• MW: 457.43
• Purity: >99.99% (May vary between batches)
• Formula: C₂₀H₂₇NO₁₁
• SMILES: O([C@@H](C#N)C1=CC=CC=C1)[C@@H]2O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O
• Target: Others
• Solubility: 10% DMSO+90% Saline:3.3 mg/mL (7.21 mM);DMSO:250 mg/mL (546.53 mM);H2O:45.74 mg/mL (99.99 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Amygdalin demonstrates efficacy in mitigating inflammatory pain, serving as an analgesic endowed with anti-nociceptive and anti-inflammatory properties. Administered intramuscularly, it notably diminishes formalin-induced tonic pain in the initial acute phase (the initial 10 min after formalin injection) as well as the persistent, late phase (10-30 min post-formalin injection). Moreover, amygdalin's pain-reduction effect escalates with increasing doses, up to a threshold of less than 1 mg/kg during the latter period.
• In Vitro:
  Amygdalin exhibits antitumor properties, with studies showing progress in elucidating its mechanism of action. Specifically, amygdalin downregulates genes related to the cell cycle, including exonuclease 1, ATP-binding cassette sub-family F, member 2, MRE11 meiotic recombination 11 homolog A, topoisomerase (DNA) I, and FK506 binding protein 12-rapamycin-associated protein 1. RT-PCR analysis has demonstrated that amygdalin treatment leads to reduced mRNA levels of these genes in SNU-C4 human colon cancer cells.
• Cell Research:
  Cell viability is determined by MTT assay. Cells are seeded in triplicate at a concentration of 1×105 cells/well on a 96-well plate. SNU-C4 cells are treated with amygdalin at concentrations of 0.25, 0.5, 2.5, and 5 mg/mL for 24 h. After MTT is added to each group, the cells are incubated for 4 h. Then, they are further incubated for 1 h, including the solution in which MTT is dissolved.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Amygdalin, inhibit, Inhibitor, Laetrile

Compound Identifiers

PubChem CID

656516