AMPC

SKU: orb1691053

Description

AMPC is a small molecule inhibitor of TFF3 that suppresses proliferation and survival in TFF3-positive CMS4 colorectal cancer cells. It demonstrates antitumor activity by inhibiting tumor growth in vivo, making it a useful compound for studying colorectal cancer mechanisms and therapeutic strategies.

Key Properties

• CAS Number: 2254434-33-6
• MW: 425.41
• Purity: 98.97% (May vary between batches)
• Formula: C₂₅H₁₆FN₃O₃
• SMILES: N#CC1=C(OC=2C=3C=CC=CC3OC(=O)C2C1C4=CC=C(C=C4)C=5C=NC(F)=C(C5)C)N
• Target: Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.75 mM);DMSO:100 mg/mL (235.07 mM)

Bioactivity

• Target IC50:
  SW480 cells:69.69 μM|SW620 cells:2.63 μM|Caco-2 cells:4.65 μM
• In Vivo:
  SW620 cells were subcutaneously injected into nude mice. The mice were randomly divided into two groups (n = 8) and intraperitoneally injected daily with AMPC at a dose of 40 mg/kg body weight or equivalent amount of vehicle for two weeks. The average tumour weight of the AMPC -treated group was significantly less than that of the vehicle-treated group. AMPC treatment resulted in larger areas of tumour necrosis and increased area of cells with apoptotic features. AMPC treatment significantly reduced tumour and serum TFF3 levels.
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• In Vitro:
  The IC50 values of AMPC in CMS4 CRC cells were determined. We observed that SW620 cells with high TFF3 expression were slightly more sensitive to AMPC than Caco2 cells with low TFF3 expression. SW620 IC50=2.63 μM; Caco2 IC50=4.65 μM; SW480 IC50=69.69 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TFF3, AMPC

Compound Identifiers

PubChem CID

142491885