AMP-Deoxynojirimycin

SKU: orb1694454

Description

AMP-Deoxynojirimycin (AMP-DNM) is a potent inhibitor of ceramide glucosyltransferase and glucosylceramidase (GCase), effectively blocking glucosylceramide (GlcCer) biosynthesis. This small molecule is utilized in research models of metabolic and neurological disorders, including diabetes and Parkinson's disease, to investigate glycosphingolipid metabolism in both cellular and animal studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 216758-20-2
• MW: 397.55
• Purity: >99.99% (May vary between batches)
• Formula: C₂₂H₃₉NO₅
• SMILES: C(OCCCCCN1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C1)C23CC4CC(C2)CC(C3)C4
• Target: Glucosidase,glycosidase,Transferase
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (5.03 mM);DMF:50 mg/mL (125.77 mM);DMSO:40 mg/mL (100.62 mM);Ethanol:20 mg/mL (50.31 mM);Ethanol:PBS(pH 7.2) (1:1):0.5 mg/mL (1.26 mM)

Bioactivity

• In Vitro:
  In 3T3-L1 cells, AMP-Deoxynojirimycin (10 μM) significantly inhibits the leucine and C17ISO-induced phosphorylation of P70S6K.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMP Deoxynojirimycin, AMPDeoxynojirimycin, AMP-Deoxynojirimycin, AMP-DNM, Glucosidase, glucosylceramide synthase

Compound Identifiers

PubChem CID

9822159