Amlodipine maleate

SKU: orb1705162

Description

Amlodipine maleate (Amvaz) is an L-type calcium channel blocker used to study hypertension. Its research applications extend to cancer studies, where it has been investigated in vitro for potential effects on cell proliferation and in vivo for vascular-related mechanisms.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 88150-47-4
• MW: 524.95
• Purity: 99.94% (May vary between batches)
• Formula: C₂₄H₂₉ClN₂O₉
• SMILES: C(=C\C(O)=O)\C(O)=O.C(OCC)(=O)C=1C(C(C(OC)=O)=C(C)NC1COCCN)C2=C(Cl)C=CC=C2
• Target: Calcium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.29 mM);DMSO:108 mg/mL (205.73 mM)

Bioactivity

• In Vivo:
  Amlodipine maleate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice. Amlodipine maleate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice.
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• In Vitro:
  Amlodipine maleate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells. Amlodipine maleate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% in A431 cells, respectively. Amlodipine maleate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Amvaz, Amlodipine Maleate, Amlodipine (+-)-form Maleate, Amlodipine (+-)-form maleate, CalciumChannel, Calcium Channel

Compound Identifiers

PubChem CID

6435922