Aminopurvalanol A

SKU: orb1306043

Description

Aminopurvalanol A is a potent, selective, and cell-permeable cyclin-dependent kinase (CDK) inhibitor. It effectively targets CDK1, CDK2, and CDK5 complexes with IC50 values in the 20-33 nM range. This compound is widely used in biochemical and cellular research to study cell cycle regulation, neuronal function, and apoptosis in both in vitro and in vivo models.

Research Area

Cell Biology

Key Properties

• CAS Number: 220792-57-4
• MW: 403.91
• Purity: 99.73% (May vary between batches)
• Formula: C₁₉H₂₆ClN₇O
• SMILES: CC(C)[C@H](CO)Nc1nc(Nc2cc(N)cc(Cl)c2)c2ncn(C(C)C)c2n1
• Target: Apoptosis,CDK
• Solubility: DMSO:55 mg/mL (136.17 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.95 mM);Ethanol:10 mg/mL (24.76 mM)

Bioactivity

• Target IC50:
  CDK5-p35:20 nM|CDK2-CyclinE:28 nM|CDK2-CyclinA:33 nM|CDK1-CyclinB:33 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

sperm fertilizing ability, inhibit, G2/M-phase transition, Inhibitor, actin polymerization, cancer cell differention, Aminopurvalanol A, Apoptosis, Cyclins, Cyclin dependent kinase, cdk5/P35, CDK2/CyclinA, cdk2/CyclinE, cdk1/CyclinB, CDK

Compound Identifiers

PubChem CID

6604931