β-Aminopropionitrile hydrochloride

SKU: orb1745130

Description

β-Aminopropionitrile hydrochloride is an orally bioavailable, irreversible inhibitor of lysyl oxidase (LOX). It has been shown to inhibit metastatic seeding in MDA-MB-231 breast cancer cell models in vitro and is used in research on fibrosis, cancer metastasis, and extracellular matrix remodeling.

Research Area

Metabolism Research, Neuroscience

Key Properties

• CAS Number: 646-03-7
• MW: 106.55
• Purity: 99.32% (May vary between batches)
• Formula: C₃H₇ClN₂
• SMILES: Cl.N#CCCN
• Target: Endogenous Metabolite,Monoamine Oxidase,Lipoxygenase

Bioactivity

• In Vivo:
  β-Aminopropionitrile hydrochloride, at a dose of 100 mg/kg/day administered orally for 6 weeks, reduced weight gain and improved metabolic profiles in diet-induced obese rats . β-Aminopropionitrile hydrochloride, at a dose of 1 g/kg/day administered orally for 4 weeks, induced thoracic aortic dissection in C57BL/6 mice .
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• In Vitro:
  In an in vitro model of insulin resistance, β-Aminopropionitrile hydrochloride can restore the expression of GLUT4 and adiponectin to normal levels and improve Vitis vinifera sugar uptake . β-Aminopropionitrile hydrochloride (500 μM, 72 hours) can block hypoxia-induced epithelial-mesenchymal transition (EMT) morphological changes and marker protein alterations in cervical squamous cell carcinoma cells, while also inhibiting their invasion and migration capabilities (in vitro experiment) .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

β-Aminopropionitrile Hydrochloride, b-Aminopropionitrile Hydrochloride, BAPN hydrochloride, BAPN Hydrochloride, beta-Aminopropionitrile Hydrochloride

Compound Identifiers

PubChem CID

12244473