β-Aminoarteether

SKU: orb1691819

Description

β-Aminoarteether (SM934 free base) is an orally bioavailable artemisinin derivative used in research on inflammation and autoimmune diseases, such as lupus. Studies demonstrate its immunomodulatory activity in both in vitro cellular assays and in vivo animal models of autoimmunity.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 133162-24-0
• MW: 327.42
• Purity: 96.09%
• Formula: C₁₇H₂₉NO₅
• SMILES: C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(O[C@@H]1OCCN)[H])[H]
• Target: NOD-like Receptor (NLR),Others
• Solubility: DMSO:60 mg/mL (183.25 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.11 mM)

Bioactivity

• In Vivo:
  Treatment with β-Aminoarteether (SM934; orally administered at doses of 1-10 mg/kg daily for 3 months) substantially slowed the advancement of glomerulonephritis and enhanced survival rates in female NZB/W F1 mice aged six and a half months . Additionally, β-Aminoarteether therapy bolstered the production of IL-10 by macrophages derived from these mice . This indicates a promising therapeutic potential for managing glomerulonephritis in this mouse model.
• In Vitro:
  β-Aminoarteether (SM934; 10 μM; 24 hours) directly increases IL-10 production and reduces IL-12/23p40 production in primary peritoneal macrophages upon IFN-γ stimulation . Additionally, in vitro, β-Aminoarteether (SM934) inhibits Th1 and Th17 polarization without affecting Treg differentiation .

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SM 934, SM934, SM-934, SM934 free base, β-Aminoarteether, b-Aminoarteether, beta-Aminoarteether

Compound Identifiers

PubChem CID

10019350