Amifostine trihydrate

SKU: orb1300818

Description

Amifostine trihydrate (WR-2721) is a cytoprotective agent clinically used to mitigate cisplatin-induced nephrotoxicity. In research, it is widely applied in oncology and radiology studies, serving as a radioprotectant in both in vivo models and in vitro cell culture experiments to investigate tissue protection mechanisms.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 112901-68-5
• MW: 268.269
• Purity: 99.80% (May vary between batches)
• Formula: C₅H₂₁N₂O₆PS
• SMILES: OP(O)(SCCNCCCN)=O.[H]O[H].[H]O[H].[H]O[H]
• Target: HIF/HIF Prolyl-Hydroxylase,MDM-2/p53
• Solubility: DMSO:Insoluble;H2O:10 mM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cytoprotective, DNA-damage, Broad-spectrum, Ethyol, HIF, HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF/HIF ProlylHydroxylase, HIF/HIFProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, MDM-2/p53, HIFProlylHydroxylase, HIF-α1, p53, WR 2721, WR2721 trihydrate, WR-2721, WR2721, thiol, radioprotector

Compound Identifiers

PubChem CID

148139