AMI-1

SKU: orb1305612

Description

AMI-1

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 20324-87-2
• MW: 548.45
• Purity: 97.53% (May vary between batches)
• Formula: C₂₁H₁₄N₂Na₂O₉S₂
• SMILES: [Na+].[Na+].Oc1cc(cc2cc(NC(=O)Nc3ccc4c(O)cc(cc4c3)S([O-])(=O)=O)ccc12)S([O-])(=O)=O
• Target: Histone Methyltransferase
• Solubility: H2O:10 mg/mL (18.23 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.02 mM);DMSO:93 mg/mL (169.57 mM)

Bioactivity

• Target IC50:
  PRMT1 (human):8.8 μM|Hmt1p (yeast):3.0 μM
• In Vivo:
  In chronic AIPI rats, AMI-1 (5 μg/rat) ameliorates COX2 expression and asthmatic indexes, and decreases the airway and alveoli lesions, mucus secretion, and collagen deposition in lungs.
• In Vitro:
  In HeLa cells, AMI-1 inhibits methylation levels of GFP-Npl3 fusion and endogenous PRMT1-like activity. AMI-1 also inhibits nuclear receptor-mediated transactivation of a luciferase reporter in MCF7 cells. In addition, AMI-1 inhibits HIV-1 RT polymerase activity with IC50 of 5 μM and inhibits DNA binding to HIV-1 RT with Kd of 2 μM. In INS-1 cells, AMI-1 improves INS-1 cell function and mediates translocations of FOXO1 and PDX-1 intracellularly by regulating FOXO1 phosphorylation and methylation.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PRMT1, PRMTs, protein arginine N-methyltransferases, yeast-Hmt1p, yeast Hmt1p, inhibit, Inhibitor, Hmt1p, Histone Methyltransferase, HistoneMethyltransferase, AMI 1, AMI1, AMI-1

Compound Identifiers

PubChem CID

88489