Amgen-23

SKU: orb1686908

Description

Amgen-23 is a potent and selective sphingosine kinase 1 (SPHK1) inhibitor with activity against SPHK2. This small molecule is a valuable research tool for investigating cancer biology, supporting both in vitro and in vivo studies of sphingolipid signaling in oncology.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1448706-15-7
• MW: 478.44
• Purity: 97.31% (May vary between batches)
• Formula: C₂₃H₂₅Cl₂N₃O₂S
• SMILES: N(C1=NC(=CS1)C2=CC(Cl)=C(Cl)C=C2)C3=CC=C(CCN4[C@@H](CO)C[C@@H](O)CC4)C=C3
• Target: S1P Receptor
• Solubility: DMSO:80 mg/mL (167.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.9 mM)

Bioactivity

• Target IC50:
  SPHK2:1.6 μM|SPHK1:20 nM
• In Vitro:
  Amgen-23 can be used for anticancer research. Amgen-23 is a potent sphingosine kinases (SPHK) inhibitor, with SPHK1 IC50 = 20 nM and SPHK2 IC50 = 1.6 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Amgen23, S1PReceptor, S1P Receptor, SPHK

Compound Identifiers

PubChem CID

71627420