AMG410 diTFA

SKU: orb3210171

Description

AMG410 diTFA is a non-covalent selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D. It exhibits over 100-fold selectivity for HRAS and NRAS. AMG410 diTFA is a dual inhibitor of both GTP (active) and GDP (inactive) states, with Kd values of 1 nM for the GDP state and 22 nM for the GTP state. The compound effectively blocks KRAS signaling without dependence on the cycling state and inhibits the proliferation of tumor cells with wild-type KRAS amplification. It is applicable for research in colorectal, pancreatic, and lung cancers.

Key Properties

• CAS Number: 3040175-18-3
• MW: 884.13
• Formula: C₃₅H₃₄ClF₈N₇O₉
• SMILES: OC(C(F)(F)F)=O.FC1=C2C3=CN=C1C4=C(CCCOC(O[C@@]5([H])CN(CCOC5)C3=NC(OC[C@@]67N(CCC7)C[C@@H](C6)F)=N2)=O)C(Cl)=CC8=C4C=NN8.OC(C(F)(F)F)=O
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras