AMG-628, (S)-

SKU: orb1740957

Description

AMG-628, the (S)-enantiomer, is a potent and selective ATP-competitive Raf kinase inhibitor. It also suppresses VEGFR2, Lyn, Flt1, and Fms activity and has demonstrated in vitro efficacy against B-RafV600E mutant colon and melanoma lines by inhibiting proliferation and inducing cell cycle arrest and apoptosis.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 862269-92-9
• MW: 492.57
• Formula: C₂₅H₂₅FN₆O₂S
• SMILES: O(C1=C2C(SC(NC(C)=O)=N2)=CC=C1)C=3C=C(N=CN3)N4CCN([C@@H](C)C5=CC=C(F)C=C5)CC4
• Target: TRP/TRPV Channel,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11317868