AMG-548

SKU: orb1710450

Description

AMG-548

Research Area

Cell Biology, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 864249-60-5
• MW: 461.56
• Purity: 99.91% (May vary between batches)
• Formula: C₂₉H₂₇N₅O
• SMILES: O=C1C(=C(N=C(NC[C@H](CC2=CC=CC=C2)N)N1C)C=3C=CN=CC3)C4=CC5=C(C=C4)C=CC=C5
• Target: p38 MAPK,Wnt/beta-catenin,TNF,Casein Kinase
• Solubility: DMSO:80 mg/mL (173.33 mM)

Bioactivity

• Target IC50:
  JNK2:39 nM (ki)|JNK1:11480 nM (ki)|p38β:3.6 nM (ki)|p38α (dog):5.0 nM (ki)|p38α:0.5 nM (ki)|p38γ:4100 nM (ki)|p38δ:2600 nM (ki)|JNK3:61 nM (ki)
• In Vivo:
  Experimental data showed that AMG-548 exhibited differentiated pharmacokinetic characteristics in different animal models: the elimination half-life (t1/2) in rats was 4.6 hours, while in canine models it was extended to 7.3 hours. In terms of bioavailability (F value), the compound reached 62% in rats, while it was relatively low at 47% in dogs. These Results indicate that AMG-548 has significant species differences, and its metabolic clearance rate and absorption efficiency vary significantly between different animal models.
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• In Vitro:
  Methods: U2OS-EFC cells were treated with AMG-548 (0.01-0.1 μM) to investigate its ability to mediate Wnt-3a-induced hDvl2 mobility shift. Results: AMG-548 inhibited hDvl2 displacement at micromolar concentrations.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CK1, dog p38α, AMG 548, AMG548, AMG-548, JNK2, JNK1, JNK3, p38β, p38γ, p38δ, p38α, p38MAPK, p38 MAPK

Compound Identifiers

PubChem CID

11167112