(±)-AMG 487

SKU: orb1704767

Description

AMG 487 is a potent and selective CXCR3 antagonist, effectively inhibiting IP-10, ITAC, and MIG-induced chemotaxis with IC50 values of 8, 15, and 36 nM, respectively. This small molecule is a valuable research tool for studying CXCR3 function in autoimmune diseases, transplant rejection, and cancer in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• MW: 603.59
• Formula: C₃₂H₂₈F₃N₅O₄
• SMILES: CCOC1=CC=C(N2C(C(N(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)CC4=CN=CC=C4)C)=NC5=C(C2=O)C=CC=N5)C=C1
• Target: Others,CXCR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

10282265