AMG-193

SKU: orb2567033

Description

AMG-193 is a small molecule inhibitor targeting the MTA-PRMT5 complex. It is utilized in preclinical research for oncology, respiratory, and digestive diseases, with studies demonstrating its activity in both cellular and animal models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2790567-82-5
• MW: 444.41
• Purity: 99.92% (May vary between batches)
• Formula: C₂₂H₁₉F₃N₄O₃
• SMILES: C(=O)(C=1C=C2C3=C(C(N)=NC2=CN1)COC3)N4[C@H](COCC4)C5=CC=C(C(F)(F)F)C=C5
• Target: Histone Methyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (11.25 mM);DMSO:80 mg/mL (180.01 mM)

Bioactivity

• Target IC50:
  HCT116 cells:0.13 μM
• In Vitro:
  AMG-193 is a PRMT5 inhibitor. AMG-193 significantly inhibited the proliferation of HCT116 cells with an IC50 value of 0.13 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMG193, Histone Methyltransferase, HistoneMethyltransferase, PRMT5

Compound Identifiers

PubChem CID

164536956