AMG-1694

SKU: orb1707669

Description

AMG-1694 is a potent small molecule disruptor of the GK-GKRP complex with an IC50 of 7 nM. It indirectly activates glucokinase, reverses GKRP-mediated inhibition, and promotes GK translocation. This compound effectively normalizes blood glucose in diabetic rodent models without inducing hypoglycemia in normoglycemic animals, making it a valuable research tool for studying type 2 diabetes pathways.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1361217-07-3
• MW: 533.63
• Purity: 98.37% (May vary between batches)
• Formula: C₂₃H₃₀F₃N₃O₄S₂
• SMILES: C([C@@H]1N(CCN(S(=O)(=O)C2=CC=CS2)C1)C3=CC=C([C@@](C(F)(F)F)(C)O)C=C3)N4[C@@H](C)COCC4
• Target: Glucokinase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.75 mM);DMSO:50 mg/mL (93.7 mM)

Bioactivity

• Target IC50:
  GK-GKRP:7 nM|GK:0.02 μM(EC50)
• In Vitro:
  AMG-1694 demonstrates high efficacy in reinstating the enzymatic activity of GK in the presence of GKRP with an EC50 of 0.020 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMG1694, AMG-1694, AMG 1694, GK-GKRP

Compound Identifiers

PubChem CID

66582747