Amfenac Sodium Hydrate

SKU: orb1307634

Description

Amfenac Sodium Hydrate is a sodium salt form of amfenac, a non-steroidal anti-inflammatory drug (NSAID) of the acetic acid class. It is used in research to study COX inhibition and inflammatory pathways, with applications in both in vitro biochemical assays and in vivo models of pain and inflammation.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 61618-27-7
• MW: 295.27
• Purity: 99.67% (May vary between batches)
• Formula: C₁₅H₁₂NO₃·H₂O·Na
• SMILES: O.[Na+].Nc1c(cccc1CC(=O)[O-])C(=O)c1ccccc1
• Target: COX
• Solubility: DMSO:3.85 mg/mL (13.04 mM);H2O:54 mg/mL (182.88 mM);Ethanol:4 mg/mL (13.55 mM)

Bioactivity

• Target IC50:
  COX-2:150 nM|COX-1:250 nM
• In Vivo:
  Amfenac significantly inhibited COX-1 (IC50=0.25 μM) and COX-2 (IC50=0.15 μM).
• In Vitro:
  Amfenac significantly inhibited COX-1 (IC50=0.25 μM) and COX-2 (IC50=0.15 μM).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclooxygenase, COX, COX-1, COX-2, Amfenac Sodium, Amfenac Sodium Hydrate, Amfenac Sodium Monohydrate, inhibit, Inhibitor

Compound Identifiers

PubChem CID

23663941