AMD-070 hydrochloride

SKU: orb1305880

Description

AMD-070 hydrochloride is a potent and selective small molecule antagonist of the CXCR4 chemokine receptor. It has demonstrated anti-HIV activity by blocking viral entry through X4 co-receptor antagonism in both in vitro cellular assays and in vivo animal models of HIV infection.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 880549-30-4
• MW: 385.93
• Purity: 99.58% (May vary between batches)
• Formula: C₂₁H₂₈ClN₅
• SMILES: C1C[C@@H](C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3.Cl
• Target: HIV Protease,CXCR
• Solubility: DMSO:60 mg/mL (155.47 mM);H2O:50 mg/mL (129.56 mM)

Bioactivity

• Target IC50:
  HIV-1 (NL4.3 strain):9 nM (In PBMCs)|HIV-1 (NL4.3 strain):3 nM (IC90, in MT-4 cells)|HIV-1 (NL4.3 strain):26 nM (IC90, in PBMCs)|HIV-1 (NL4.3 strain):1 nM (In MT-4 cells)|125 I-CXCL12-CXCR4:13 nM
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CXCR4, AMD 070 Hydrochloride, AMD070 hydrochloride, AMD070 Hydrochloride, AMD 070 hydrochloride, AMD-070 Hydrochloride

Compound Identifiers

PubChem CID

71576687