Ambroxol hydrochloride

SKU: orb1300953

Description

Ambroxol hydrochloride, the active metabolite of bromhexine, is a mucolytic agent that enhances mucociliary clearance to improve airway patency. It is widely used in respiratory research, with applications in both in vitro studies of mucus rheology and in vivo models of pulmonary diseases such as bronchitis and COPD.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 23828-92-4
• MW: 414.56
• Purity: 99.70%
• Formula: C₁₃H₁₈Br₂N₂O·HCl
• SMILES: Cl.NC1=C(Br)C=C(Br)C=C1CN[C@H]1CC[C@H](O)CC1
• Target: glycosidase,Autophagy,Glucosidase,Sodium Channel
• Solubility: DMSO:50 mg/mL (120.61 mM)

Bioactivity

• Target IC50:
  Na+ channel:35.2 μM-22.5 μM
• In Vivo:
  Ambroxol acts as a charged local anesthetic in CNaIIA cells, exhibiting blockade that is dependent on the number of stimulations and increases with the frequency of a series of depolarizing stimuli. In CNaIIA cells, Ambroxol's inhibition rate for inactivated channels is 5.5 times higher than that for resting channels. Ambroxol differentially affects the kinetics of Na+ currents in TTX-r (tetrodotoxin-resistant) and TTX-s (tetrodotoxin-sensitive) channels, with the response factor for TTX-r channels being only 3.3. Additionally, Ambroxol inhibits Na+ channels in sensory neurons, showing a higher potency in blocking TTX-r channels. Ambroxol also inhibits the release of histamine, leukotrienes, and cytokines from human leukocytes and mast cells.
• In Vitro:
  At a concentration of 100 μM, Ambroxol significantly inhibits the release of histamine, LTC4, IL-4, and IL-13 induced by IgE antibodies in basophils, and reduces the release of histamine and LTB4 in monocytes triggered by C5a or yeast polysaccharide. Ambroxol also suppresses the release of histamine by more than 50% in human adenoid hypertrophy (1000 μM Ambroxol) and skin hypertrophy mast cells (100 μM Ambroxol) stimulated by ConA and compound 48/80, respectively. Furthermore, Ambroxol decreases the production of LTB4 and superoxide anion in granulocytes stimulated by yeast polysaccharides or fMLP.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

chaperone, disease, Autophagy, Bromhexine, Ambroxol HCl, Ambroxol Hydrochloride, Ambroxol hydrochloride, Ambroxol, inhibit, Mucosolvan, Mucoangin, Parkinson, NA 872, NA872, NA-872, neuronopathic, GCase, Inhibitor, Gaucher, Glucosidase, glucocerebrosidase, expectorant, SodiumChannel, Sodium Channel

Compound Identifiers

PubChem CID

108013