Ambenonium

SKU: orb1737736

Description

Ambenonium (WIN 8077) is a potent, orally active, and reversible acetylcholinesterase (AChE) inhibitor with an IC50 of 0.7 nM. It is used in research for myasthenia gravis, facilitating studies on neuromuscular junction function in both in vitro enzymatic assays and in vivo pharmacological models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 7648-98-8
• MW: 537.57
• Formula: C₂₈H₄₂Cl₂N₄O₂
• SMILES: O=C(NCC[N+](CC=1C=CC=CC1Cl)(CC)CC)C(=O)NCC[N+](CC=2C=CC=CC2Cl)(CC)CC
• Target: Others

Bioactivity

• Target IC50:
  BChE (human):8.2 μM|AChE (human):0.0007 μM
• In Vitro:
  Ambenonium inhibited human AChE with high potency (IC₅₀ = 0.0007 μM; Ellman’s method; 20 min incubation), and showed strong selectivity over BChE (IC₅₀ = 8.2 μM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ambestigmin chloride, Ambenonii chloridum, Ambenonium Chloride, Ambenonium dichloride, Mytelase, Misuran, WIN 8077, WIN8077

Compound Identifiers

PubChem CID

2131