AM-8123

SKU: orb1691307

Description

AM-8123 is a nonpeptide, orally bioavailable APJ receptor agonist. It has demonstrated efficacy in reducing cardiac collagen deposition and improving function in rat models of myocardial infarction, making it a useful research tool for studying heart failure and related cardiovascular pathologies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2049973-02-4
• MW: 567.66
• Purity: 99.76% (May vary between batches)
• Formula: C₂₇H₃₃N₇O₅S
• SMILES: N(S([C@H]([C@@H](OC(C)C)C=1N=CC(C)=CN1)C)(=O)=O)C=2N(C(=NN2)C=3C=C(C)C=NC3)C4=C(OC)C=CC=C4OC
• Target: Apelin receptor

Bioactivity

• In Vivo:
  In 2-3-month-old Lewis rats, AM-8123 (100 mg/kg; oral administration) resulted in sustained improvement in systolic function. Additionally, echocardiography measurements showed that AM-8123 reduced end-diastolic volume (EDV) and end-systolic volume (ESV); however, no significant changes were observed by invasive pressure-volume conductance catheter measurements at the end of the study.
• In Vitro:
  AM-8123 inhibits histamine-stimulated cAMP production and promotes Gα protein activation.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AM8123, AM-8123, AM 8123, APJ, Apelinreceptor, Apelin receptor

Compound Identifiers

PubChem CID

122702584