AM-6494

SKU: orb1710454

Description

AM-6494 is a potent, orally bioavailable small molecule inhibitor that selectively targets BACE1 over BACE2, with IC50 values of 0.4 nM and 18.6 nM, respectively. It is a valuable research tool for investigating BACE1 function in Alzheimer's disease pathogenesis through both in vitro enzymatic assays and in vivo model studies.

Research Area

Neuroscience

Key Properties

• CAS Number: 1874232-80-0
• MW: 473.5
• Formula: C₂₂H₂₁F₂N₅O₃S
• SMILES: C(OC)[C@]12[C@]([C@](C)(N=C(N)S1)C3=CC(NC(=O)C=4C=NC(OCC#C)=CN4)=CC(F)=C3F)(C2)[H]
• Target: BACE,Beta-Secretase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

118866105