AM-5308

SKU: orb1686312

Description

AM-5308 is a selective small molecule inhibitor of the mitotic kinesin KIF18A. It is a valuable research tool for studying cell division mechanisms and has been used in both in vitro and in vivo models to investigate novel oncology and anti-cancer therapeutic strategies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2410796-89-1
• MW: 529.65
• Purity: 99.58% (May vary between batches)
• Formula: C₂₆H₃₅N₅O₅S
• SMILES: C(NC=1N=C(C=CC1)N2C[C@@H](C)OCC2)(=O)C3=C(N4CCC5(CC5)CC4)C=C(NS(CCO)(=O)=O)C=C3
• Target: Microtubule Associated,Kinesin
• Solubility: DMSO:80 mg/mL (151.04 mM)

Bioactivity

• In Vivo:
  Mice with established tumors were administered vehicle, AM-1882 at 50 or 100 mg per kg or AM-5308 at 25 or 50 mg/kg daily for 18 d. AM-1882 and AM-5308 inhibited tumor growth with evidence of tumor regression.
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• In Vitro:
  AM-5308 and AM-1882 have a favorable in vitro profile against a panel of normal cell types, which is distinct from myelosuppressive and neurotoxic anti-mitotic agents. Nevertheless, higher micromolar concentrations of AM-5308 and AM-1882 may adversely affect normal cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AM5308, mitotic kinesin Kif18A, Microtubule Associated, MicrotubuleAssociated

Compound Identifiers

PubChem CID

153625074