ALW-II-49-7

SKU: orb1685604

Description

ALW-II-49-7 is a potent and selective small molecule inhibitor of the EphB2 receptor tyrosine kinase, demonstrating an EC50 of 40 nM in cellular assays. It is a valuable research tool for studying EphB2 signaling in cancer biology and neurodevelopment, with utility in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1135219-23-6
• MW: 414.38
• Purity: 99.84% (May vary between batches)
• Formula: C₂₁H₁₇F₃N₄O₂
• SMILES: N(C1=CC(C(NC2=CC(C(F)(F)F)=CC=C2)=O)=CC=C1C)C=3C=C(C(N)=O)C=NC3
• Target: Ephrin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.83 mM);DMSO:25 mg/mL (60.33 mM)

Bioactivity

• In Vitro:
  ALW-II-49-7 (0.01-10 μ M; 1 h) inhibits the activity of EphB2 kinase in U87 glioblastoma cells at a concentration of 2 μ g/mL.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ephrin Receptor, EphB2, EphrinReceptor, ALWII497, ALW-II-49-7

Compound Identifiers

PubChem CID

24875320