ALW-II-41-27

SKU: orb1302934

Description

ALW-II-41-27 is a small molecule inhibitor targeting Eph receptor tyrosine kinases, utilized in oncology research. It is applied in both in vitro and in vivo studies to investigate pathways involved in tumor growth and metastasis, supporting the development of novel cancer therapeutics.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1186206-79-0
• MW: 607.69
• Purity: 99.52% (May vary between batches)
• Formula: C₃₂H₃₂F₃N₅O₂S
• SMILES: CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(NC(=O)c4cncc(c4)-c4cccs4)c3)cc2C(F)(F)F)CC1
• Target: Ephrin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.29 mM);DMSO:55 mg/mL (90.51 mM)

Bioactivity

• Target IC50:
  Eph family tyrosine kinase:11 nM
• In Vitro:
  ALW-II-41-27 inhibits Ba/F3 cells (EC50<500 nM) transformed with Tel fusions of Kit, EphA3, Fms, KDR, FLT1, FGR, Src, Bmx, Lyn, and Bcr-Abl, and shows cross-reactivity with Bcr-Abl. Additionally, ALW-II-41-27 inhibits b-Raf, CSF1R, DDR1, DDR2, EphA2, EphA8, EphB1, EphB2, Kit, EphB3, Frk, Lck, EphA5, p38α, p38β, PDGFRβ, PDGFRα, and Raf1.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ALW II 41 27, ALWII4127, ALW-II-41-27, Inhibitor, Ephrin Receptor, EphrinReceptor, Eph receptor tyrosine kinase inhibitor, inhibit

Compound Identifiers

PubChem CID

42628503