ALW-II-41-27

SKU: orb1302934

Description

ALW-II-41-27

Research Area

Signal Transduction

Key Properties

• CAS Number: 1186206-79-0
• MW: 607.69
• Purity: 99.48%
• Formula: C₃₂H₃₂F₃N₅O₂S
• SMILES: CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(NC(=O)c4cncc(c4)-c4cccs4)c3)cc2C(F)(F)F)CC1
• Target: Ephrin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.29 mM);DMSO:55 mg/mL (90.51 mM)

Bioactivity

• Target IC50:
  Eph family tyrosine kinase:11 nM
• In Vitro:
  ALW-II-41-27 inhibits Ba/F3 cells (EC5 < 00 nM) transformed with Tel fusions of Kit, EphA3, Fms, KDR, FLT1, FGR, Src, Bmx, Lyn, and Bcr-Abl, and shows cross-reactivity with Bcr-Abl. Additionally, ALW-II-41-27 inhibits b-Raf, CSF1R, DDR1, DDR2, EphA2, EphA8, EphB1, EphB2, Kit, EphB3, Frk, Lck, EphA5, p38α, p38β, PDGFRβ, PDGFRα, and Raf1.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

ALW II 41 27, ALWII4127, ALW-II-41-27, Inhibitor, Ephrin Receptor, EphrinReceptor, Eph receptor tyrosine kinase inhibitor, inhibit

Compound Identifiers

PubChem CID

42628503