Altretamine

SKU: orb1309268

Description

Altretamine (ENT-50852) is a small molecule alkylating agent used in cancer research. It has demonstrated antineoplastic activity in both in vitro cell-based assays and in vivo animal models, particularly in the study of ovarian cancer.

Research Area

Molecular Biology

Key Properties

• CAS Number: 645-05-6
• MW: 210.28
• Purity: 99.84%
• Formula: C₉H₁₈N₆
• SMILES: N(C)(C)C=1N=C(N(C)C)N=C(N(C)C)N1
• Target: DNA Alkylator/Crosslinker,DNA Alkylation
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (2.38 mM);DMSO:8.4 mg/mL (39.95 mM);Ethanol:8 mg/mL (38.04 mM)

Bioactivity

• In Vitro:
  In elevated plus-maze and light/dark tests in BAL-/- mice, Flumazenil (1 mg/kg) exhibited strong anxiolytic effects. Flumazenil (3 mg/kg) prevented alterations induced by chronic ethanol withdrawal in mice, such as decreased open arm time and percentage of open arm entries. In rats, Flumazenil (10 mg/kg) effectively counteracte the reductive effects of tetrahydropregnanolone. Flumazenil (5-20 mg/kg) antagonize the effects of diazepam in mice without affectin the anticonvulsant and adverse responses to GYKI52466. in the MES model, as opposed to the PTZ test, Flumazenil slightly reduce the anticonvulsant activity of NBQX. Flumazenil binds to central benzodiazepine (BZD) receptors, thereby antagonizing or reversin the neurophysiological effects of BZD depressants and agonists. It reverse the depressant sedative responses caused b the combined use of BZD and Other drugs but is not effective for cyclic antidepressant overdose.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNAAlkylator, DNAAlkylation, DNA Alkylator/Crosslinker, DNA Alkylating, DNA Alkylation, DNA Alkylator, Crosslinker, Altretamine, inhibit, NSC 13875, NSC13875, NSC-13875, Hexamethylmelamine, Inhibitor, ENT 50852, ENT-50852, ENT50852, WR95704, WR-95704, WR 95704, RB 1515, RB1515, RB-1515

Compound Identifiers

PubChem CID

2123