Altretamine

SKU: orb1309268

Description

Altretamine (ENT-50852) is a small molecule alkylating agent used in cancer research. It has demonstrated antineoplastic activity in both in vitro cell-based assays and in vivo animal models, particularly in the study of ovarian cancer.

Research Area

Cell Biology

Key Properties

• CAS Number: 645-05-6
• MW: 210.3
• Purity: >98%
• Formula: C₉H₁₈N₆
• SMILES: N(C)(C)C=1N=C(N(C)C)N=C(N(C)C)N1
• Target: Glutathione
• Solubility: Soluble in DMSO (40 mg/ml)

Bioactivity

• In Vitro:
  In elevated plus-maze and light/dark tests in BALB/c mice, Flumazenil (1 mg/kg) exhibited strong anxiolytic effects. Flumazenil (3 mg/kg) prevented alterations induced by chronic ethanol withdrawal in mice, such as decreased open arm time and percentage of open arm entries. In rats, Flumazenil (10 mg/kg) effectively counteracted the reductive effects of tetrahydropregnanolone. Flumazenil (5-20 mg/kg) antagonized the effects of diazepam in mice without affecting the anticonvulsant and adverse responses to GYKI52466. In the MES model, as opposed to the PTZ test, Flumazenil slightly reduced the anticonvulsant activity of NBQX. Flumazenil binds to central benzodiazepine (BZD) receptors, thereby antagonizing or reversing the neurophysiological effects of BZD depressants and agonists. It reverses the depressant sedative responses caused by the combined use of BZD and other drugs but is not effective for cyclic antidepressant overdose.

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hexamethylmelamine; NSC-13875

Compound Identifiers

PubChem CID

2123