Alternariol

SKU: orb1707683

Description

Alternariol

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 641-38-3
• MW: 258.229
• Formula: C₁₄H₁₀O₅
• SMILES: Cc1cc(O)cc2oc(=O)c3c(O)cc(O)cc3c12
• Target: Others
• Solubility: DMSO:20 mg/mL (77.45 mM)

Bioactivity

• In Vivo:
  Alternariol was administered via intravenous injection (1-5 mg/kg, once daily for 4 consecutive days), demonstrating embryotoxicity and immunotoxicity in mice during embryonic and infant developmental stages, while also triggering apoptosis . In a DMBA-induced breast cancer mouse model, Alternariol (50-200 mg/kg, orally administered once daily for 24 weeks) significantly suppressed breast cancer progression by inducing apoptosis and inhibiting cell proliferation .
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• In Vitro:
  Treatment of human lung epithelial cells (BEAS-2B) and mouse macrophages (RAW264.7) with Alternariol (10 μM, 24 h) can inhibit the innate immune response of both cell types . Alternariol (5-10 μM, 24 h) reduces LPS-induced inflammatory response in BEAS-2B cells in a dose-dependent manner . Alternariol (1-100 μM, 24 h) exerts an inhibitory effect on the proliferation of BEAS-2B cells and induces cell cycle arrest . In V79 cells and mouse lymphoma L5178Y tk+/− cells (MLC), Alternariol (10 μM, 24 h) can induce mutations in the HPRT and TK genes .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alternariol

Compound Identifiers

PubChem CID

5359485