Alsterpaullone

SKU: orb1299829

Description

Alsterpaullone is a potent cyclin-dependent kinase (CDK) inhibitor that induces apoptosis in HeLa cells. This small molecule is utilized in biochemical and cell biology research to study cell cycle regulation, apoptosis mechanisms, and CDK function in various in vitro cancer models.

Research Area

Cardiovascular Research, Cell Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 237430-03-4
• MW: 293.2
• Purity: >96%
• Formula: C₁₆H₁₁N₃O₃
• SMILES: [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
• Target: Kinase
• Solubility: Soluble in DMSO (up to 10 mg/ml).

Bioactivity

• Target IC50:
  CDK5-p35:40 nM|CDK2-CyclinA:15 nMCD|K2/Cyc E:200 nM|CDK1-CyclinB:35 nM|GSK-3α:4|GSK-3β:4 nM
• In Vitro:
  Alsterpaullone inhibited HeLa cells in a time-dependent (0-72 h) and dose-dependent (0-30 μ M) manner. In the presence of alsterpaullone, HeLa cells were arrested in G2/M prior to undergoing apoptosis via a mechanism that is involved in the regulation of various antiapoptotic genes, DNA-repair, transcription, and cell cycle progression. Compared to controls, alsterpaullone effectively prevented HeLa cells from entering S-phase. These potential therapeutic efficacies could be correlated with the activation of caspase-3.

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p35, Glycogen synthase kinase-3, Glycogen synthase kinase 3, GSK3, GSK-3, Inhibitor, NSC705701, NSC-705701, neurodegenerative, NSC 705701, inhibit, antitumor, Apoptosis, 9-Nitropaullone, ALSTERPAULLONE, Cyclin dependent kinase, cyclin B, cyclin A, cyclin E, CDK2, CDK5, CDK, CDK1

Compound Identifiers

PubChem CID

5005498